Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Retinoschisis
ADR ID BADD_A08559
ADR Hierarchy
06      Eye disorders
06.09      Ocular structural change, deposit and degeneration NEC
06.09.03      Retinal structural change, deposit and degeneration
06.09.03.025      Retinoschisis
Description A vitreoretinal dystrophy characterized by splitting of the neuroretinal layers. It occurs in two forms: degenerative retinoschisis and X chromosome-linked juvenile retinoschisis. | Splitting of the RETINA into two layers at the level of the outer plexiform layer, beginning as a cystic degeneration in the extreme retinal periphery. It usually occurs after 40 years of age and is generally not progressive. | X chromosome recessive disorder, found nearly exclusively in males and becoming apparent around puberty. Characterized initially by a cystlike structure involving the FOVEA CENTRALIS, a peripheral retinoschisis occurs in about half the patients. [MeSH]
MedDRA Code 10061492
MeSH ID D041441
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Bullous retinoschisis | Flat retinoschisis | Other retinoschisis and retinal cysts | Retinal layer separation | Retinal layer separation, unspecified | Retinoschisis and retinal cysts | Retinoschisis NOS | Retinoschisis, unspecified | Separation of retinal layers | Retinoschisis | Retinoschises | Retinoschisis, Degenerative | Degenerative Retinoschises | Degenerative Retinoschisis | Retinoschises, Degenerative | Retinoschisis, Juvenile, X-Linked | Retinoschisis, Juvenile | Juvenile Retinoschises | Juvenile Retinoschisis | Retinoschises, Juvenile | Congenital X-Linked Retinoschisis | Congenital X Linked Retinoschisis | Congenital X-Linked Retinoschises | Retinoschises, Congenital X-Linked | Retinoschisis, Congenital X-Linked | X-Linked Retinoschises, Congenital | X-Linked Retinoschisis, Congenital | Retinoschisis, Juvenile, X Chromosome-Linked | X-Linked Juvenile Retinoschisis | Juvenile Retinoschises, X-Linked | Juvenile Retinoschisis, X-Linked | Retinoschises, X-Linked Juvenile | Retinoschisis, X-Linked Juvenile | X Linked Juvenile Retinoschisis | X-Linked Juvenile Retinoschises | Retinoschisis X-Linked Juvenile | Retinoschisis, X-Linked | Retinoschises, X-Linked | Retinoschisis, X Linked | X-Linked Retinoschises | X-Linked Retinoschisis | X Linked Retinoschisis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00407Cefuroxime0.000429%
BADD_D01653Paclitaxel0.000112%
BADD_D01835Pregabalin0.000052%
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