Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Metastases to meninges
ADR ID BADD_A08059
ADR Hierarchy
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.22      Metastases
16.22.02      Metastases to specified sites
16.22.02.003      Metastases to meninges
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.10      Nervous system disorders NEC
17.02.10.012      Metastases to meninges
Description Primary or secondary neoplasm in the ARACHNOID or SUBARACHNOID SPACE. It appears as a diffuse fibrotic thickening of the MENINGES associated with variable degrees of inflammation. [MeSH]
MedDRA Code 10051696
MeSH ID D055756
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Leptomeningeal metastases | Metastases to meninges | Meningeal carcinoma | Melanomatous meningitis | Meningeal carcinomatosis | Lymphomatous meningitis | Neoplastic meningitis | Leptomeningeal disease | Meningeal dissemination | Meningeal Carcinomatosis | Carcinomatoses, Meningeal | Carcinomatosis, Meningeal | Meningeal Carcinomatoses | Carcinomatous Meningitis | Carcinomatous Meningitides | Meningitides, Carcinomatous | Meningitis, Carcinomatous | Leptomeningeal Carcinomatosis | Carcinomatoses, Leptomeningeal | Carcinomatosis, Leptomeningeal | Leptomeningeal Carcinomatoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000334%
BADD_D00047Afatinib0.001903%
BADD_D00349Capecitabine0.000224%
BADD_D00364Carboplatin0.000168%
BADD_D00367Carfilzomib0.000112%
BADD_D00414Ceritinib0.000168%
BADD_D00535Crizotinib0.000112%
BADD_D00623Dexamethasone0.000145%
BADD_D00775Enzalutamide0.000501%
BADD_D00798Eribulin0.000224%
BADD_D00800Erlotinib0.000112%
BADD_D00858Everolimus0.000229%
BADD_D00978Fulvestrant0.001001%
BADD_D01008Gefitinib0.001119%
BADD_D01110Hydroxyurea0.000112%
BADD_D01258Leucovorin0.001859%
BADD_D01378Memantine0.000242%
BADD_D01418Methotrexate0.000171%
BADD_D01567Nilotinib0.000112%
BADD_D01601Olaparib0.000336%
BADD_D01629Osimertinib0.003470%
BADD_D02111Tamoxifen--
BADD_D02150Temozolomide0.000448%
BADD_D02257Trametinib0.000112%
BADD_D02270Tretinoin0.000107%
BADD_D02344Vemurafenib0.000448%
BADD_D02464Fingolimod0.000362%
BADD_D02480Alectinib--
BADD_D02483Ribociclib0.000112%
BADD_D02509Brigatinib0.000280%
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