Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Infantile spasms
ADR ID BADD_A07316
ADR Hierarchy
17      Nervous system disorders
17.12      Seizures (incl subtypes)
17.12.03      Seizures and seizure disorders NEC
17.12.03.027      Infantile spasms
19      Psychiatric disorders
19.21      Cognitive and attention disorders and disturbances
19.21.02      Cognitive and attention disorders and disturbances NEC
19.21.02.011      Infantile spasms
Description An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8) [MeSH]
MedDRA Code 10021750
MeSH ID D013036
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Hypsarrythmia | Infantile spasms | Infantile spasms, with intractable epilepsy | Infantile spasms, without mention of intractable epilepsy | Salaam attacks | Hypsarrhythmia | Salaam's tic | West's syndrome | Spasms, Infantile | Infantile Spasm | Infantile Spasms | Lightning Attacks | Attack, Lightning | Attacks, Lightning | Lightning Attack | West Syndrome | Syndrome, West | Hypsarrhythmias | Jackknife Seizures | Jackknife Seizure | Seizure, Jackknife | Seizures, Jackknife | Symptomatic Infantile Spasms | Infantile Spasm, Symptomatic | Infantile Spasms, Symptomatic | Spasm, Symptomatic Infantile | Spasms, Symptomatic Infantile | Symptomatic Infantile Spasm | Symptomatic West Syndrome | Syndrome, Symptomatic West | West Syndrome, Symptomatic | Salaam Attacks | Attacks, Salaam | Salaam Seizures | Seizures, Salaam | Spasmus Nutans | Cryptogenic Infantile Spasms | Cryptogenic Infantile Spasm | Infantile Spasm, Cryptogenic | Infantile Spasms, Cryptogenic | Spasm, Cryptogenic Infantile | Spasms, Cryptogenic Infantile | Cryptogenic West Syndrome | Syndrome, Cryptogenic West | West Syndrome, Cryptogenic | Nodding Spasm | Nodding Spasms | Spasm, Nodding | Spasms, Nodding
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00356Carbamazepine0.000186%
BADD_D00488Clobazam0.000287%
BADD_D00501Clonazepam0.000030%
BADD_D00858Everolimus0.000306%
BADD_D01265Levetiracetam0.000358%
BADD_D01418Methotrexate0.000114%
BADD_D01637Oxcarbazepine0.000170%
BADD_D02010Sertraline0.000038%
BADD_D02247Topiramate0.000226%
BADD_D02329Valproic acid0.000300%
BADD_D02355Vigabatrin0.003549%
BADD_D02396Zonisamide0.000414%
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