Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02236Tofacitinib--
BADD_D02237Tofacitinib citrate--
BADD_D02246Tolvaptan0.000378%
BADD_D02247Topiramate0.000226%
BADD_D02250Toremifene citrate0.000334%
BADD_D02253Trabectedin0.000224%
BADD_D02261Tranexamic acid0.003117%
BADD_D02329Valproic acid0.002167%
BADD_D02346Venlafaxine0.000145%
BADD_D02360Vincristine0.000112%
BADD_D02369Voriconazole0.142309%
BADD_D02373Warfarin0.000463%
BADD_D02396Zonisamide0.000622%
BADD_D02436Atorvastatin0.000070%
BADD_D02442Magnesium oxide0.000182%
BADD_D02445Solifenacin0.000174%
BADD_D02470Nintedanib--
BADD_D02473Sodium chloride0.001207%
BADD_D02480Alectinib0.000280%
BADD_D02504Lorlatinib0.000728%
BADD_D02509Brigatinib0.000168%
BADD_D02530Avacopan0.000241%
BADD_D02540Capmatinib0.000112%
BADD_D02550Diroximel fumarate0.000241%
BADD_D02577Oseltamivir acid0.000991%
BADD_D02588Remdesivir0.001129%
BADD_D02596Sotorasib0.000224%
BADD_D02603Tucatinib0.000112%
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