Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Peripheral arterial occlusive disease
ADR ID BADD_A06121
ADR Hierarchy
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.03      Peripheral vasoconstriction, necrosis and vascular insufficiency
24.04.03.010      Peripheral arterial occlusive disease
Description Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION. [MeSH]
MedDRA Code 10062585
MeSH ID D001162; D058729
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Arterial insufficiency peripheral | Atherosclerosis obliterans | Atherosclerosis of arteries of the extremities | Atherosclerosis of arteries of the extremities with gangrene | Atherosclerosis of arteries of the extremities with intermittent claudication | Atherosclerosis of arteries of the extremities with rest pain | Atherosclerosis of arteries of the extremities with ulceration | Atherosclerosis of arteries of the extremities, unspecified | Atherosclerosis of autologous vein bypass graft of the extremities | Atherosclerosis of bypass graft of the extremities | Atherosclerosis of nonautologous vein bypass graft of the extremities | Atherosclerosis of unspecified graft of the extremities | Obstructive arteriosclerosis of lower extremities | Other atherosclerosis of arteries of the extremities | Atherosclerosis of non-autologous vein bypass graft of the extremities | Critical limb ischemia | Critical limb ischaemia | Peripheral occlusive disease | Peripheral arterial occlusive disease | Arteriosclerosis obliterans | Atherosclerosis obliterans aggravated | Peripheral arterial occlusive disease aggravated | Peripheral arterial disease | Peripheral obliterative arteriopathy | Peripheral arteriosclerosis | Peripheral arterial occlusive disease Fontaine stage I | Peripheral arterial occlusive disease Fontaine stage IIa | Peripheral arterial occlusive disease Fontaine stage IIb | Peripheral arterial occlusive disease Fontaine stage III | Peripheral arterial occlusive disease Fontaine stage IV | Critical limb-threatening ischaemia | Critical limb-threatening ischemia | Chronic limb-threatening ischemia | Chronic limb-threatening ischaemia | Chronic limb ischemia | Chronic limb ischaemia | Infrainguinal occlusive disease | Arteriosclerosis Obliterans | Obliterans, Arteriosclerosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01954Rivaroxaban0.000614%
BADD_D01971Rosuvastatin0.000034%
BADD_D02026Simvastatin0.000018%
BADD_D02058Sorafenib0.000246%
BADD_D02105Tacrolimus0.000594%
BADD_D02170Testosterone0.000245%
BADD_D02214Ticagrelor0.000408%
BADD_D02337Varenicline0.000428%
BADD_D02373Warfarin0.000056%
BADD_D02434Cinacalcet0.000586%
BADD_D02493Selinexor0.000112%
BADD_D02514Etelcalcetide0.005753%
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