Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Type III immune complex mediated reaction
ADR ID BADD_A05281
ADR Hierarchy
10      Immune system disorders
10.01      Allergic conditions
10.01.03      Allergic conditions NEC
10.01.03.023      Type III immune complex mediated reaction
Description A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis. [MeSH]
MedDRA Code 10053614
MeSH ID D001183
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Arthus phenomenon | Arthus reaction | Arthus-type reaction | Type III hypersensitivity reaction | Immunocomplex mediated hypersensitivity | Type III immune complex mediated reaction | Immune complex formation | Immune complex reaction | Immune complex deposition | Arthus Reaction | Reaction, Arthus | Arthus Phenomenon | Phenomenon, Arthus
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00129Amoxicillin0.000005%
BADD_D00230Bendamustine0.000112%
BADD_D00284Bortezomib--
BADD_D00653Diclofenac0.000026%
BADD_D00771Enfuvirtide--
BADD_D01081Hydralazine0.000136%
BADD_D01083Hydrochlorothiazide0.000010%
BADD_D01633Oxaliplatin0.000336%
BADD_D01834Prednisone--
BADD_D01856Propafenone0.000418%
BADD_D02093Sulfasalazine--
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