Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation of palms | Palmoplantar hyperpigmentation | Increased skin pigmentation | Periorbital hyperpigmentation | Hyperpigmentation | Hypermelanoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02273Triamcinolone diacetate--
BADD_D02274Triamcinolone hexacetonide--
BADD_D02281Trifluoperazine--
BADD_D02316Unoprostone--
BADD_D02317Unoprostone isopropyl--
BADD_D02329Valproic acid0.000349%
BADD_D02344Vemurafenib0.000358%
BADD_D02345Venetoclax0.000112%
BADD_D02369Voriconazole0.005809%
BADD_D02411Voxelotor-
BADD_D02450Crisaborole0.003015%
BADD_D02464Fingolimod0.001423%
BADD_D02558Gadolinium cation (3+)-
BADD_D02575Omadacycline0.000131%
BADD_D02586Radium ra-223 dichloride-
BADD_D02601Trifarotene0.018381%
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ADReCS-Target
ADR Term Drug Name Target