Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation of palms | Palmoplantar hyperpigmentation | Increased skin pigmentation | Periorbital hyperpigmentation | Hyperpigmentation | Hypermelanoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01803Porfimer sodium--
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01831Prednisolone0.000035%
BADD_D01832Prednisolone acetate--
BADD_D01834Prednisone0.000035%
BADD_D01846Procarbazine--
BADD_D01847Procarbazine hydrochloride--
BADD_D01854Promethazine0.000038%
BADD_D01925Rescinnamine--
BADD_D01936Rifampicin--
BADD_D01971Rosuvastatin0.000058%
BADD_D02008Sertaconazole--
BADD_D02009Sertaconazole nitrate--
BADD_D02010Sertraline0.000047%
BADD_D02021Siltuximab--
BADD_D02031Sitaxentan--
BADD_D02062Sparfloxacin--
BADD_D02100Sunitinib0.000571%
BADD_D02105Tacrolimus--
BADD_D02120Tazarotene--
BADD_D02154Tenofovir0.004265%
BADD_D02160Terbinafine0.000521%
BADD_D02203Thiotepa--
BADD_D02247Topiramate0.000050%
BADD_D02253Trabectedin--
BADD_D02265Travoprost--
BADD_D02270Tretinoin--
BADD_D02271Triamcinolone--
BADD_D02272Triamcinolone acetonide--
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ADReCS-Target
ADR Term Drug Name Target