Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer sodium
Drug ID BADD_D01803
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status approved; investigational
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
UNII Y3834SIK5F
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010---
Abdominal pain upper07.01.05.003--
Abdominal rigidity07.01.05.011---
Agitation17.02.05.012; 19.06.02.001--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Asthenia08.01.01.001---
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Back pain15.03.04.005--
Basal cell carcinoma16.03.02.001; 23.08.02.001---
Blister12.01.06.002; 23.03.01.001---
Blood albumin decreased13.09.01.001---
Blood chloride increased13.11.01.005---
Blood urea increased13.13.01.006---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Breath odour07.01.06.002---
Bronchial obstruction22.03.01.013--
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Bronchostenosis22.03.01.020--
Burning sensation08.01.09.029; 17.02.06.001---
Cardiac failure02.05.01.001--
Cataract06.06.01.001--
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