Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Optic ischaemic neuropathy
ADR ID BADD_A03175
ADR Hierarchy
17      Nervous system disorders
17.04      Cranial nerve disorders (excl neoplasms)
17.04.05      Optic nerve disorders NEC
17.04.05.006      Optic ischaemic neuropathy
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.10      Retinal necrosis and vascular insufficiency
24.04.10.001      Optic ischaemic neuropathy
06      Eye disorders
06.07      Ocular haemorrhages and vascular disorders NEC
06.07.03      Optic nerve bleeding and vascular disorders
06.07.03.001      Optic ischaemic neuropathy
Description Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) [MeSH]
MedDRA Code 10030924
MeSH ID D018917
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Ischemic optic neuropathy | Optic ischaemic neuropathy | Optic ischemic neuropathy | Ischaemic optic neuropathy | Nonarteritic ischemic optic neuropathy | Arteritic ischemic optic neuropathy | Nonarteritic ischaemic optic neuropathy | Arteritic ischaemic optic neuropathy | Nonarteritic anterior ischaemic optic neuropathy | Anterior ischaemic optic neuropathy | Arteritic anterior ischaemic optic neuropathy | NAION | AION | AAION | Nonarteritic anterior ischemic optic neuropathy | Anterior ischemic optic neuropathy | Arteritic anterior ischemic optic neuropathy | Optic Neuropathy, Ischemic | Ischemic Optic Neuropathy | Ischemic Optic Neuropathies | Neuropathies, Ischemic Optic | Neuropathy, Ischemic Optic | Optic Neuropathies, Ischemic | Optic Nerve Ischemia | Ischemia, Optic Nerve | Ischemias, Optic Nerve | Nerve Ischemia, Optic | Nerve Ischemias, Optic | Optic Nerve Ischemias | Posterior Ischemic Optic Neuropathy | Optic Neuropathy, Posterior Ischemic | Anterior Ischemic Optic Neuropathy | Optic Neuropathy, Anterior Ischemic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00115Amiodarone0.001616%
BADD_D00151Apixaban0.000087%
BADD_D00178Atenolol0.000019%
BADD_D00192Avanafil--
BADD_D00194Azacitidine0.000112%
BADD_D00504Clopidogrel0.000021%
BADD_D00563Dabigatran0.000245%
BADD_D00623Dexamethasone0.000218%
BADD_D00898Finasteride0.000112%
BADD_D00932Fluoxetine0.000039%
BADD_D01081Hydralazine0.000102%
BADD_D01136Imatinib0.000112%
BADD_D01243Lamotrigine0.000221%
BADD_D01281Levonorgestrel0.000709%
BADD_D01322Losartan0.000010%
BADD_D01366Medroxyprogesterone acetate--
BADD_D01473Minoxidil0.000701%
BADD_D01566Nifedipine0.000075%
BADD_D01567Nilotinib0.000224%
BADD_D01599Olanzapine0.000421%
BADD_D01614Omeprazole--
BADD_D01615Omeprazole magnesium--
BADD_D01633Oxaliplatin0.000280%
BADD_D01654Palbociclib0.000302%
BADD_D01668Pantoprazole0.000016%
BADD_D01834Prednisone0.000009%
BADD_D01895Quinine0.000734%
BADD_D01933Ribavirin0.005934%
BADD_D02010Sertraline0.000013%
BADD_D02018Sildenafil0.000913%
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