Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Necrosis
ADR ID BADD_A02982
ADR Hierarchy
08      General disorders and administration site conditions
08.03      Tissue disorders NEC
08.03.03      Necrosis NEC
08.03.03.001      Necrosis
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.02      Non-site specific necrosis and vascular insufficiency NEC
24.04.02.006      Necrosis
Description The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process. [MeSH]
MedDRA Code 10028851
MeSH ID D009336
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Necrosis | Necrosis NOS | Coagulation necrosis | Colliquation necrosis | Liquefactive necrosis | Necroses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02100Sunitinib0.000280%
BADD_D02105Tacrolimus0.000594%
BADD_D02149Temoporfin--
BADD_D02150Temozolomide0.000336%
BADD_D02176Tetracaine--
BADD_D02182Tetradecyl hydrogen sulfate (ester)--
BADD_D02222Tinzaparin sodium--
BADD_D02253Trabectedin--
BADD_D02272Triamcinolone acetonide0.000041%
BADD_D02329Valproic acid0.000150%
BADD_D02332Vancomycin--
BADD_D02346Venlafaxine--
BADD_D02364Vinorelbine tartrate--
BADD_D02369Voriconazole0.017426%
BADD_D02373Warfarin0.000238%
BADD_D02374Warfarin sodium--
BADD_D02393Zolmitriptan--
BADD_D02423Fondaparinux0.014802%
BADD_D02475Methylene blue0.000183%
BADD_D02483Ribociclib0.000112%
BADD_D02498Abemaciclib0.000112%
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ADReCS-Target
ADR Term Drug Name Target