Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Temoporfin
Drug ID BADD_D02149
Description Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Foscan.
Indications and Usage For use in the treatment of patients with advanced squamous cell carcinoma of the head and neck failing standard therapies and who are unsuitable for radiotherapy, surgery, or systemic chemotherapy [FDA Label].
Marketing Status approved; investigational
ATC Code L01XD05
DrugBank ID DB11630
KEGG ID D06066
MeSH ID C072269
PubChem ID 60751
TTD Drug ID D0P5DG
NDC Product Code Not Available
UNII FU21S769PF
Synonyms temoporfin | m-THPC | mTHPC | meso-tetrahydroxyphenyl chlorin | meso-tetrahydroxyphenylchlorin | 5,10,15,20-tetra(m-hydroxyphenyl)chlorin | meso-tetra-(hydroxyphenyl)chlorin | Foscan | Foslip
Chemical Information
Molecular Formula C44H32N4O4
CAS Registry Number 122341-38-2
SMILES C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7 )O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Blister12.01.06.002; 23.03.01.001---
Body temperature increased13.15.01.001---
Bone disorder15.02.04.004---
Burning sensation08.01.09.029; 17.02.06.001---
Constipation07.02.02.001--
Dermatitis bullous23.03.01.002--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysphagia07.01.06.003--
Erythema23.03.06.001---
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Facial pain08.01.08.012--
Fistula15.03.02.001---
Gastrointestinal disorder07.11.01.001---
Haemoglobin13.01.05.018---
Headache17.14.01.001--
Infection11.01.08.002---
Injection site pain08.02.03.010; 12.07.03.011---
Injection site reaction08.02.03.014; 12.07.03.015--
Localised infection11.01.08.006---
Mouth ulceration07.05.06.004---
Nausea07.01.07.001--
Necrosis08.03.03.001; 24.04.02.006---
Nervous system disorder17.02.10.001---
Oedema08.01.07.006; 14.05.06.010---
Pain08.01.08.004--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Photosensitivity reaction23.03.09.003--
Sepsis11.01.11.003--
Skin disorder23.03.03.007---
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