Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hypothyroidism
ADR ID BADD_A02222
ADR Hierarchy
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.012      Hypothyroidism
05      Endocrine disorders
05.02      Thyroid gland disorders
05.02.03      Thyroid hypofunction disorders
05.02.03.001      Hypothyroidism
Description A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland. [CTCAE] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. [MeSH]
MedDRA Code 10021114
MeSH ID D007037
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acquired hypothyroidism | Acquired hypothyroidism other | Hypothyroidism | Iodine hypothyroidism | Myxedema juvenile | Other iatrogenic hypothyroidism | Other specified acquired hypothyroidism | Thyroid activity decreased | Thyroid function decreased | Unspecified hypothyroidism | Myxoedema juvenile | Latent hypothyroidism | Subclinical hypothyroidism | Hypothyreosis | Drug-induced hypothyroidism | Borderline hypothyroidism | Refractory hypothyroidism | Hypothyroidisms | Primary Hypothyroidism | Hypothyroidism, Primary | Primary Hypothyroidisms | Thyroid-Stimulating Hormone Deficiency | Deficiency, Thyroid-Stimulating Hormone | Hormone Deficiency, Thyroid-Stimulating | Thyroid Stimulating Hormone Deficiency | Thyroid-Stimulating Hormone Deficiencies | TSH Deficiency | Deficiency, TSH | TSH Deficiencies | Secondary Hypothyroidism | Hypothyroidism, Secondary | Secondary Hypothyroidisms | Central Hypothyroidism | Central Hypothyroidisms | Hypothyroidism, Central
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02147Telmisartan0.000260%
BADD_D02189Tetrasodium;iron(3+);nitroxyl anion;pentacyanide--
BADD_D02192Thalidomide--
BADD_D02203Thiotepa--
BADD_D02210Tiagabine--
BADD_D02211Tiagabine hydrochloride--
BADD_D02230Tizanidine--
BADD_D02231Tizanidine hydrochloride--
BADD_D02234Tocilizumab--
BADD_D02247Topiramate0.000151%
BADD_D02252Tositumomab--
BADD_D02254Tramadol--
BADD_D02329Valproic acid0.000549%
BADD_D02331Valsartan0.000132%
BADD_D02334Vandetanib--
BADD_D02346Venlafaxine--
BADD_D02369Voriconazole--
BADD_D02379Zaleplon--
BADD_D02389Ziprasidone hydrochloride--
BADD_D02391Ziprasidone mesylate--
BADD_D02407Upadacitinib--
BADD_D02412Octreotide0.000559%
BADD_D02436Atorvastatin--
BADD_D02440Lisdexamfetamine0.000271%
BADD_D02464Fingolimod--
BADD_D02473Sodium chloride--
BADD_D02490Apalutamide0.002803%
BADD_D02504Lorlatinib0.000392%
BADD_D02528Asciminib0.000246%
BADD_D02546Daprodustat0.000198%
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