Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Cholangitis sclerosing
ADR ID BADD_A00899
ADR Hierarchy
09      Hepatobiliary disorders
09.02      Bile duct disorders
09.02.01      Bile duct infections and inflammations
09.02.01.003      Cholangitis sclerosing
10      Immune system disorders
10.04      Autoimmune disorders
10.04.09      Hepatic autoimmune disorders
10.04.09.002      Cholangitis sclerosing
Description Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS. [MeSH]
MedDRA Code 10008609
MeSH ID D015209
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cholangitis sclerosing | Primary sclerosing cholangitis | Sclerosing cholangitis | IgG4 related cholangiopathy | Cholangitis, Sclerosing | Cholangitides, Sclerosing | Sclerosing Cholangitides | Sclerosing Cholangitis | Cholangiitis, Sclerosing | Cholangiitides, Sclerosing | Sclerosing Cholangiitides | Sclerosing Cholangiitis | Primary Sclerosing Cholangitis | Cholangitides, Primary Sclerosing | Primary Sclerosing Cholangitides | Sclerosing Cholangitides, Primary | Sclerosing Cholangitis, Primary | Cholangitis, Primary Sclerosing
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00195Azathioprine0.000627%
BADD_D00382Cefazolin0.000122%
BADD_D00414Ceritinib0.000112%
BADD_D00680Dimethyl fumarate--
BADD_D00723Doxorubicin0.000168%
BADD_D00725Doxycycline0.000100%
BADD_D01213Isotretinoin0.005918%
BADD_D01228Ketamine0.000357%
BADD_D01397Mesalamine--
BADD_D01567Nilotinib0.000112%
BADD_D01834Prednisone--
BADD_D01951Risperidone0.000970%
BADD_D01989Saquinavir mesylate--
BADD_D02026Simvastatin0.000011%
BADD_D02105Tacrolimus0.000594%
BADD_D02321Ursodiol--
BADD_D02392Zoledronic acid--
BADD_D02464Fingolimod0.000482%
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