Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Anencephaly
ADR ID BADD_A00222
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.10      Neurological disorders congenital
03.10.03      Cerebral disorders congenital
03.10.03.001      Anencephaly
17      Nervous system disorders
17.19      Congenital and peripartum neurological conditions
17.19.03      Congenital and peripartum cerebral disorders
17.19.03.001      Anencephaly
Description A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247) [MeSH]
MedDRA Code 10002320
MeSH ID D000757
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Anencephalia | Anencephalus | Anencephalus and similar anomalies | Anencephaly | Congenital Absence of Brain | Brain Congenital Absence | Absence of Brain, Congenital | Anencephalias | Incomplete Anencephaly | Anencephaly, Incomplete | Partial Anencephaly | Anencephalies, Partial | Anencephaly, Partial | Partial Anencephalies | Hemicranial Anencephaly | Anencephaly, Hemicranial | Aprosencephaly | Aprosencephalies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00419Cetrorelix--
BADD_D00421Cetrorelix trifluoroacetate--
BADD_D00497Clomiphene--
BADD_D00498Clomiphene citrate--
BADD_D00749Efavirenz--
BADD_D00871Felbamate--
BADD_D01366Medroxyprogesterone acetate--
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