Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cetrorelix
Drug ID BADD_D00419
Description Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur.
Indications and Usage For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
Marketing Status approved; investigational
ATC Code H01CC02
DrugBank ID DB00050
KEGG ID D07665
MeSH ID C062876
PubChem ID 25074887
TTD Drug ID D09OLZ
NDC Product Code 41524-0013; 78848-005
UNII OON1HFZ4BA
Synonyms cetrorelix | N-acetyl-1-(3-(2-naphthyl)alanine)-2-(4-chlorophenylalanine)-3-(3-(3-pyridyl)alanine)-6-citrulline-10-alanine-LHRH | LHRH, N-Ac-1-Nal(2)-2-Phe(pCl)-3-Pal(3)-6-Cit-10-Ala- | LHRH, N-acetyl-1-(3-(2-naphthyl)alanyl)-2-(4-chlorophenylalanyl)-3-(3-(3-pyridyl)alanyl)-6-citrulline-10-alanine- | SB 75 | SB-75 | Cetrotide | cetrorelix acetate | cetrorelix pamoate
Chemical Information
Molecular Formula C70H92ClN17O14
CAS Registry Number 120287-85-6
SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCNC(=O)N)NC(=O )C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(= O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Anencephaly03.10.03.001; 17.19.03.001---
Assisted fertilisation25.10.04.001---
Congenital anomaly03.02.01.001---
Cough22.02.03.001--
Dermatitis23.03.04.002---
Developmental delay08.01.03.037; 19.07.05.003---
Developmental glaucoma03.01.05.001; 06.03.02.001---
Diaphragmatic hernia07.16.01.002; 22.09.02.001---
Erythema23.03.06.001---
Glaucoma06.03.01.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Imperforate hymen03.03.04.001; 21.08.01.004---
Klinefelter's syndrome03.20.05.001; 05.05.02.005---
Local reaction08.01.03.012---
Melanocytic naevus16.26.01.007; 23.10.01.007---
Menopausal symptoms21.02.02.002---
Nausea07.01.07.001--
Ovarian disorder21.11.02.004---
Pruritus23.03.12.001--
Rash23.03.13.001---
Stillbirth08.04.01.006; 18.01.02.002---
Supernumerary nipple03.03.03.001; 21.05.04.020---
Swelling08.01.03.015---
Trisomy 2102.08.02.003; 03.20.01.002; 17.03.07.005; 19.21.06.005---
Ventricular septal defect02.04.02.007; 03.07.02.001---
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
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