| Pharmaceutical Information |
| Drug Name |
Revefenacin |
| Drug ID |
BADD_D02589 |
| Description |
Revefenacin is a novel biphenyl carbamate tertiary amine agent that belongs to the family of the long-acting muscarinic antagonists (LABA). The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic clearance and minimizing of the systemically mediated adverse reactions. The LABA group falls into a parent category known as long-acting inhaled bronchodilators and this type of agents are recommended as a maintenance therapy for chronic obstructive pulmonary disease (COPD).[A40025] From the LABA group, revefenacin is the first once-daily nebulized LAMA treatment.[A40026] It was developed by Theravance Biopharma and FDA approved on November 9, 2018.[L4818] |
| Indications and Usage |
Revefenacin is indicated as an inhalation solution for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).[L4820]
COPD is a growing disease being the third leading cause of death in the US. This disease is characterized by not fully reversible airflow limitation.[L4821] |
| Marketing Status |
approved; investigational |
| ATC Code |
R03BB08 |
| DrugBank ID |
DB11855
|
| KEGG ID |
D10978
|
| MeSH ID |
C583570
|
| PubChem ID |
11753673
|
| TTD Drug ID |
D0K1ST
|
| NDC Product Code |
62009-1912; 59651-683; 53296-0127; 16436-0127; 49502-806; 54893-0122 |
| UNII |
G2AE2VE07O
|
| Synonyms |
revefenacin | Yupelri | TD-4208 | biphenyl-2-ylcarbamic acid 1-(2-((4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl)methylamino)ethyl)piperidin-4-yl ester |
|
| Chemical Information |
| Molecular Formula |
C35H43N5O4 |
| CAS Registry Number |
864750-70-9 |
| SMILES |
CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)CN5CCC(CC5)C(=O)N |
| Chemical Structure |
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| ADRs Induced by Drug |
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