Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pacritinib
Drug ID BADD_D02581
Description Pacritinib is under investigation for the prevention of Acute Myeloid Leukemia (AML).
Indications and Usage Not Available
Marketing Status investigational
ATC Code L01EJ03
DrugBank ID DB11697
KEGG ID D11768
MeSH ID C561234
PubChem ID 46216796
TTD Drug ID D0PN8H
NDC Product Code 72482-100
UNII G22N65IL3O
Synonyms 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | pacritinib | SB 1518 | SB1518 | SB-1518
Chemical Information
Molecular Formula C28H32N4O3
CAS Registry Number 937272-79-2
SMILES C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC(=CC=C4)C5=NC(=NC=C5)NC(=C3)C=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.0010.000246%
Death08.04.01.0010.000504%
Diarrhoea07.02.01.0010.001959%
Drug ineffective08.06.01.0060.000951%-
Epistaxis22.04.03.001; 24.07.01.0050.000381%
Fatigue08.01.01.0020.000761%
Feeling abnormal08.01.09.0140.000381%-
Malaise08.01.01.0030.000571%
Nausea07.01.07.0010.000761%
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.000437%
Pain in extremity15.03.04.0100.000381%
Pyrexia08.05.02.0030.000246%
Thrombocytopenia01.08.01.0020.000112%-
Haemorrhage24.07.01.0020.000246%-
Adverse event08.06.01.0100.000381%-
Disease progression08.01.03.0380.000112%
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