| Pharmaceutical Information |
| Drug Name |
Glasdegib |
| Drug ID |
BADD_D02559 |
| Description |
Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of the benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with a low molecular weight, potent inhibitory activity and lacking unstable functionality. The great lipophilicity of this group of compounds brought interest to further modification. This analysis concluded that the presence of p-cyano ureas presented good physicochemical and pharmacokinetic properties from which glasdegib was developed.[A40310]
Glasdegib was developed by Pfizer Inc and approved on November 21, 2018, by the FDA for the treatment of Acute Myeloid Leukemia.[L11935] |
| Indications and Usage |
Glasdegib, in combination with cytarabine, is indicated for the treatment of newly diagnosed acute myeloid leukemia in adult patients who are over 75 years old or that have co-morbidities that preclude intensive induction chemotherapy.[L5080]
Acute myeloid leukemia is characterized by abnormal production of myeloblasts, red cells, or platelets. It is considered a cancer of blood and bone marrow and it is the most common type of acute leukemia in adults.[L4832] |
| Marketing Status |
approved; investigational |
| ATC Code |
L01XJ03 |
| DrugBank ID |
DB11978
|
| KEGG ID |
D10636
|
| MeSH ID |
C000592580
|
| PubChem ID |
25166913
|
| TTD Drug ID |
D0S5LO
|
| NDC Product Code |
0069-0298; 0069-1531 |
| UNII |
K673DMO5H9
|
| Synonyms |
glasdegib | Daurismo | 1-(2-(1H-benzo(d)imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea | PF-04449913 |
|
| Chemical Information |
| Molecular Formula |
C21H22N6O |
| CAS Registry Number |
1095173-27-5 |
| SMILES |
CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N |
| Chemical Structure |
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| ADRs Induced by Drug |
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