Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levomilnacipran
Drug ID BADD_D02466
Description Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, levomilnacipran is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.
Indications and Usage Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD).
Marketing Status approved; investigational
ATC Code N06AX28
DrugBank ID DB08918
KEGG ID D10072
MeSH ID D000078862
PubChem ID 6917779
TTD Drug ID D02XOK
NDC Product Code 65162-960; 65162-411; 65162-437; 65162-455; 68554-0115
UNII UGM0326TXX
Synonyms Levomilnacipran | Fetzima | Levomilnacipran Hydrochloride
Chemical Information
Molecular Formula C15H22N2O
CAS Registry Number 96847-54-0
SMILES CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aggression19.05.01.001---
Agitation17.02.05.012; 19.06.02.0010.000200%
Anger19.04.02.0010.000275%-
Anxiety19.06.02.0020.000275%
Atrial fibrillation02.03.03.0020.000062%
Cerebrovascular accident17.08.01.007; 24.03.05.0010.000062%
Completed suicide08.04.01.010; 19.12.01.0010.000062%-
Constipation07.02.02.0010.000212%
Crying08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.0020.000137%-
Depression19.15.01.0010.000137%
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000306%
Drug hypersensitivity10.01.01.0010.000137%-
Drug ineffective08.06.01.006---
Dyspnoea02.11.05.003; 22.02.01.004--
Dysuria20.02.02.002--
Ejaculation disorder21.03.01.002--
Feeling jittery08.01.09.0160.000137%-
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.0160.000062%
Headache17.14.01.0010.000318%
Hepatic failure09.01.03.0020.000062%
Hyperhidrosis08.01.03.028; 23.02.03.0040.000350%
Hypersensitivity10.01.03.0030.000212%
Hypertension24.08.02.0010.000350%
Insomnia17.15.03.002; 19.02.01.0020.000212%
Irritability08.01.03.011; 19.04.02.0130.000062%
Malaise08.01.01.0030.000212%
Malignant hypertension24.08.01.0020.000062%-
Muscle spasms15.05.03.0040.000137%
Nausea07.01.07.0010.000655%
Nightmare19.02.03.0030.000137%-
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