| Pharmaceutical Information |
| Drug Name |
Vorinostat |
| Drug ID |
BADD_D02370 |
| Description |
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier studies). Further brain tumor trials are planned using combinations of vorinostat with other drugs. |
| Indications and Usage |
For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. |
| Marketing Status |
approved; investigational |
| ATC Code |
L01XH01 |
| DrugBank ID |
DB02546
|
| KEGG ID |
D06320
|
| MeSH ID |
D000077337
|
| PubChem ID |
5311
|
| TTD Drug ID |
D0E7PQ
|
| NDC Product Code |
0006-0568; 63285-009 |
| UNII |
58IFB293JI
|
| Synonyms |
Vorinostat | N1-Hydroxy-N8-phenyloctanediamide | N1 Hydroxy N8 phenyloctanediamide | NHNPODA | Suberoyl Anilide Hydroxamic Acid | Suberoylanilide Hydroxamic Acid | N-Hydroxy-N'-phenyloctanediamide | N Hydroxy N' phenyloctanediamide | Suberanilohydroxamic Acid | M344 | MK-0683 | MK 0683 | MK0683 | 18F-SAHA | 18F-Suberoylanilide Hydroxamic Acid | 18F Suberoylanilide Hydroxamic Acid | Zolinza |
|
| Chemical Information |
| Molecular Formula |
C14H20N2O3 |
| CAS Registry Number |
149647-78-9 |
| SMILES |
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
|
|
|
