Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vernakalant hydrochloride
Drug ID BADD_D02351
Description Vernakalant was developed by Cardiome Pharma as as an antiarrhythmic drug intended for rapid conversion of atrial fibrillation to sinus rhythm. It acts as an atypical class III antiarrhythmic drug that potentiates its effect in higher heart rates. Intravenous formulation was approved in Europe in September 2010 as Brinavess and in Canada in April 2017. It is an investigational drug under regulatory review by FDA.
Indications and Usage Indicated for the rapid conversion of recent onset of atrial fibrillation to sinus rhythm in adults for non-surgery patients that lasts for less than 7 days of duration and post-cardiac surgery patients with atrial fibrillation lasting less than 3 days of duration.
Marketing Status approved; investigational
ATC Code C01BG11
DrugBank ID DB06217
KEGG ID D06665
MeSH ID C524581
PubChem ID 9930048
TTD Drug ID D00OTL
NDC Product Code Not Available
UNII 7G4J1ZD9UQ
Synonyms vernakalant | RSD 1235 | RSD1235 | RSD-1235
Chemical Information
Molecular Formula C20H32ClNO4
CAS Registry Number 748810-28-8
SMILES COC1=C(C=C(C=C1)CCOC2CCCCC2N3CCC(C3)O)OC.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal disorder07.11.01.001---
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypotension24.06.03.002--
Lacrimation increased06.08.02.004--
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002---
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Pain in extremity15.03.04.010--
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Palpitations02.11.04.012--
Paraesthesia17.02.06.005; 23.03.03.094--
Parosmia17.04.04.002; 22.04.03.007---
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.010--
Pruritus23.03.12.001--
Rhinorrhoea22.12.03.021--
Sinus arrest02.03.03.007---
Sinus bradycardia02.03.03.009--
Skin disorder23.03.03.007---
Sneezing22.12.03.024--
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Throat irritation07.05.05.037; 22.12.03.029---
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007---
Ventricular tachycardia02.03.04.010--
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