Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valrubicin
Drug ID BADD_D02330
Description Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Indications and Usage For the treatment of cancer of the bladder.
Marketing Status approved
ATC Code L01DB09
DrugBank ID DB00385
KEGG ID D02697
MeSH ID C016163
PubChem ID 454216
TTD Drug ID D07IPB
NDC Product Code 67979-001; 77391-005
UNII 2C6NUM6878
Synonyms valrubicin | N-trifluoroacetyladriamycin 14-valerate | Valtaxin | Valstar | AD 32 | AD-32 | NSC-246131
Chemical Information
Molecular Formula C34H36F3NO13
CAS Registry Number 56124-62-0
SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O 5)C)O)NC(=O)C(F)(F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Micturition urgency20.02.02.006--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nocturia20.02.03.001---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Pain08.01.08.0040.000571%
Pelvic pain07.01.06.012; 20.02.03.007; 21.10.01.001--
Pneumonia11.01.09.003; 22.07.01.003---
Pollakiuria20.02.02.007--
Proctalgia07.03.02.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000437%
Rash23.03.13.0010.000571%-
Skin irritation23.03.04.009---
Urethral pain20.02.02.014---
Urethritis11.01.14.008; 20.07.02.001--
Urge incontinence20.02.02.0080.002149%-
Urinary incontinence17.05.01.008; 20.02.02.0100.000627%
Urinary retention20.02.02.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urine flow decreased20.02.02.012---
Vomiting07.01.07.003--
Bladder spasm20.02.02.0130.001142%
Musculoskeletal discomfort15.03.04.001---
Thermal burn12.05.04.001; 23.03.11.042--
Rectal tenesmus07.03.03.001; 15.05.03.011---
Vasodilation procedure25.03.01.001---
Ill-defined disorder08.01.03.0490.000571%-
Disease progression08.01.03.0380.000112%
Drug intolerance08.06.01.0130.000571%-
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