Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil sodium
Drug ID BADD_D02269
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D08628
MeSH ID C427248
PubChem ID 23663413
TTD Drug ID D01WUA
NDC Product Code 68245-0009; 14501-0016; 40016-009; 58159-040; 82231-115; 54893-0022
UNII 7JZ75N2NT6
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H33NaO5
CAS Registry Number 289480-64-4
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.001--
Cellulitis11.02.01.001; 23.11.02.004---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspnoea02.11.05.003; 22.02.01.004--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hypotension24.06.03.002--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010---
Pain in jaw15.02.01.003---
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Pruritus23.03.12.001--
Rash23.03.13.001---
Rash papular23.03.13.017---
Right ventricular failure02.05.03.002---
Thrombocytopenia01.08.01.002---
Thrombophlebitis24.01.02.001---
Vasodilatation23.06.05.006; 24.03.02.003---
Infusion related reaction08.01.03.002; 10.01.01.017; 12.02.05.009--
Infusion site pain08.02.05.014; 12.07.05.002---
Infusion site reaction08.02.05.005; 12.07.05.006---
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