Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thioguanine
Drug ID BADD_D02199
Description An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Indications and Usage For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.
Marketing Status approved
ATC Code L01BB03
DrugBank ID DB00352
KEGG ID D06109
MeSH ID D013866
PubChem ID 2723601
TTD Drug ID D02ZXM
NDC Product Code 76388-880; 50683-0356; 80725-630; 69784-630
UNII FTK8U1GZNX
Synonyms Thioguanine | 2-Amino-6-Purinethiol | 2 Amino 6 Purinethiol | Tioguanine | 6-Thioguanine | 6 Thioguanine | Tabloid | Thioguanine Tabloid | Thioguanin-GSK | Thioguanin GSK | ThioguaninGSK | Tioguanina Wellcome | Thioguanine Hemihydrate | Thioguanine Monosodium Salt | Lanvis | Thioguanine Anhydrous | Anhydrous, Thioguanine
Chemical Information
Molecular Formula C5H5N5S
CAS Registry Number 154-42-7
SMILES C1=NC2=C(N1)C(=S)N=C(N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alcohol abuse19.07.06.001---
Alcoholism19.07.06.006---
Ascites02.05.04.002; 07.07.01.001; 09.01.05.003--
Blood uric acid increased13.02.04.001---
Fibrosis08.03.01.001---
Fluid retention14.05.06.002; 20.01.02.003---
Gastrointestinal necrosis07.15.01.003; 24.04.08.006--
Hepatic necrosis09.01.07.002--
Hepatomegaly09.01.05.001---
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010---
Hyperuricaemia14.09.01.003--
Intestinal perforation07.04.06.002---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Nausea07.01.07.001--
Pancytopenia01.03.03.003---
Peliosis hepatis09.01.07.010---
Portal hypertension09.01.06.006; 24.08.06.001--
Splenomegaly01.09.02.001---
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002---
Venoocclusive liver disease09.01.06.002; 12.02.09.039; 24.04.07.002--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Nodular regenerative hyperplasia09.01.04.004---
Varices oesophageal07.15.05.001; 09.01.06.009; 24.10.02.004---
Decreased appetite08.01.09.028; 14.03.01.005--
Venoocclusive disease24.03.02.016---
Bone marrow failure01.03.03.005--
Cytopenia01.03.03.012---
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