| Pharmaceutical Information |
| Drug Name |
Telavancin hydrochloride |
| Drug ID |
BADD_D02144 |
| Description |
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others. |
| Indications and Usage |
For the treatment of complicated skin and skin structure infections (cSSSI) caused by gram-positive bacteria like methicillin-susceptible or -resistant Staphylococcus aureus, vancomycin-susceptible Enterococcus faecalis, and Streptococcus pyogenes, Streptococcus agalactiae, or Streptococcus anginosus group. Also for the treatment of adult patients with hospital-acquired bacterial pneumonia (HAP) and ventilator-associated bacterial pneumonia (VAP), known or suspected to be caused by susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant S. aureus). |
| Marketing Status |
approved |
| ATC Code |
J01XA03 |
| DrugBank ID |
DB06402
|
| KEGG ID |
D06057
|
| MeSH ID |
C487637
|
| PubChem ID |
9812715
|
| TTD Drug ID |
D02IJB
|
| NDC Product Code |
65129-3104; 66220-315; 42513-0012 |
| UNII |
0701472ZG0
|
| Synonyms |
telavancin | TD 6424 | TD6424 | TD-6424 | Vibativ | telavancin hydrochloride |
|
| Chemical Information |
| Molecular Formula |
C80H107Cl3N11O27P |
| CAS Registry Number |
560130-42-9 |
| SMILES |
CCCCCCCCCCNCCNC1(CC(OC(C1O)C)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)N
C(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C(=C(C=C9C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)
O)NC7=O)C(=O)O)O)CNCP(=O)(O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)C.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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