Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sugammadex sodium
Drug ID BADD_D02085
Description Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Indications and Usage Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Marketing Status approved
ATC Code V03AB35
DrugBank ID DB06206
KEGG ID D05940
MeSH ID D000077122
PubChem ID 6918584
TTD Drug ID Not Available
NDC Product Code 53296-0119; 59651-409; 69037-0050; 76397-034; 62227-016; 69575-4041; 83137-0005; 51846-1056; 11722-068; 42973-233; 69766-065; 12860-0001; 63850-8099; 71796-003; 76397-033; 16436-0119; 65129-1418; 76397-030; 62147-0278; 82393-301
UNII ERJ6X2MXV7
Synonyms Sugammadex | Org 25969 | Sugammadex Sodium | 6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt | Bridion
Chemical Information
Molecular Formula C72H104Na8O48S8
CAS Registry Number 343306-71-8
SMILES C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O) O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-] )CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O) [O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Light anaesthesia25.01.03.003---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Pain08.01.08.004--
Rash erythematous23.03.13.029---
Swelling08.01.03.015---
Swollen tongue07.14.02.003; 10.01.05.015; 23.04.01.014---
Tachycardia02.03.02.007---
Urethral disorder20.07.01.002---
Urinary tract disorder20.08.01.001---
Urticaria10.01.06.001; 23.04.02.001--
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Unwanted awareness during anaesthesia12.02.20.010---
Angiopathy24.03.02.007---
Anaesthetic complication12.02.20.002---
Cardiac disorder02.11.01.003---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Malnutrition14.03.02.004---
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Postoperative wound complication12.02.05.019---
Grimacing17.02.05.029---
Procedural hypotension12.02.05.026; 24.06.03.010---
Procedural hypertension12.02.05.037; 24.08.02.012---
Procedural pain08.01.08.009; 12.02.05.007---
Recurrence of neuromuscular blockade12.02.20.009; 17.05.04.006---
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