Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Saxagliptin hydrochloride
Drug ID BADD_D01993
Description Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Indications and Usage Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
Marketing Status approved
ATC Code A10BH03
DrugBank ID DB06335
KEGG ID D10262
MeSH ID C502994
PubChem ID 49800073
TTD Drug ID D0Y6QC
NDC Product Code 55111-960; 50370-0039
UNII Z8J84YIX6L
Synonyms saxagliptin | 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate | Onglyza | BMS 477118 | BMS477118 | BMS-477118
Chemical Information
Molecular Formula C18H26ClN3O2
CAS Registry Number 709031-78-7
SMILES C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Gastroenteritis07.19.03.001; 11.01.07.004---
Headache17.14.01.001--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Infection11.01.08.002---
Lymphocyte count decreased13.01.06.006--
Lymphopenia01.02.02.002---
Nasopharyngitis11.01.13.002; 22.07.03.002---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Rash23.03.13.001---
Sinusitis11.01.13.005; 22.07.03.007--
Thrombocytopenia01.08.01.002---
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
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