ADReCS

Pharmaceutical Information

Drug Name	Saxagliptin
Drug ID	BADD_D01992
Description	Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Indications and Usage	Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
Marketing Status	approved
ATC Code	A10BH03
DrugBank ID	DB06335
KEGG ID	D08996
MeSH ID	C502994
PubChem ID	11235729
TTD Drug ID	D0K9MY
NDC Product Code	50193-4212; 0310-6100; 0310-6105; 11722-078; 0310-7100; 50370-0030; 55154-6931; 0310-7105
UNII	9GB927LAJW
Synonyms	saxagliptin \| 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate \| Onglyza \| BMS 477118 \| BMS477118 \| BMS-477118

Chemical Information

Molecular Formula	C18H25N3O2
CAS Registry Number	361442-04-8
SMILES	C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal distension	07.01.04.001	0.000720%
Abdominal pain	07.01.05.002	0.001539%
Abdominal pain upper	07.01.05.003	0.001211%
Acidosis	14.01.03.002	0.000327%
Acute abdomen	07.01.06.015	0.000327%		-
Acute myocardial infarction	02.02.02.001; 24.04.04.001	0.000655%		-
Anaphylactic reaction	10.01.07.001; 24.06.03.006	-	-
Anaphylactic shock	10.01.07.002; 24.06.02.004	-	-	-
Angioedema	10.01.05.009; 22.04.02.008; 23.04.01.001	0.000491%		-
Arrhythmia	02.03.02.001	0.001048%		-
Arthralgia	15.01.02.001	0.004059%
Asthenia	08.01.01.001	0.000982%		-
Back pain	15.03.04.005	0.000884%
Bladder cancer	16.08.01.001; 20.03.04.001	0.000655%		-
Blood creatine phosphokinase increased	13.04.01.001	-	-
Blood creatinine increased	13.13.01.004	-	-
Blood triglycerides increased	13.12.03.001	-	-	-
Breast cancer	16.10.01.001; 21.05.01.003	0.000327%		-
Cardiac failure	02.05.01.001	0.002946%
Cardiac failure acute	02.05.01.005	0.000327%		-
Cardiac failure congestive	02.05.01.002	0.000982%		-
Cerebral infarction	17.08.01.004; 24.04.06.002	0.001146%		-
Cerebrovascular accident	17.08.01.007; 24.03.05.001	0.000655%
Chest discomfort	02.02.02.009; 08.01.08.019; 22.12.02.002	0.000491%		-
Chest pain	02.02.02.011; 08.01.08.002; 22.12.02.003	0.000655%		-
Chills	08.01.09.001; 15.05.03.016	0.000327%
Cholecystitis	09.03.01.001	0.000327%
Cholelithiasis	09.03.01.002	0.001048%		-
Circulatory collapse	24.06.02.001	0.000327%		-
Constipation	07.02.02.001	0.001048%

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