Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol xinafoate
Drug ID BADD_D01982
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage Salmeterol is indicated in the treatment of asthma with an inhaled corticosteroid, prevention of exercise induced bronchospasm, and the maintenance of airflow obstruction and prevention of exacerbations of chronic obstructive pulmonary disease.[L11545,L11548,L11551,L11554,L11557]
Marketing Status approved
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D00687
MeSH ID D000068299
PubChem ID 56801
TTD Drug ID D0L5YV
NDC Product Code 53104-7541; 50909-4102; 64567-0007; 52221-109; 52482-002; 15308-1021; 63190-0650; 14501-0045; 55018-402; 58032-0143; 0173-0521
UNII 6EW8Q962A5
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C36H45NO7
CAS Registry Number 94749-08-3
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010---
Oral candidiasis07.05.07.001; 11.03.03.004---
Pain08.01.08.004--
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Paraesthesia17.02.06.005; 23.03.03.094--
Pharyngeal oedema10.01.05.016; 22.04.05.003; 23.04.01.016---
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Photosensitivity reaction23.03.09.003--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Rhinitis11.01.13.004; 22.07.03.006--
Sinus congestion22.04.06.001---
Sinus headache17.14.01.002; 22.12.03.022--
Sinusitis11.01.13.005; 22.07.03.007--
Sleep disorder19.02.04.001---
Stridor22.04.02.003--
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015---
Throat irritation07.05.05.037; 22.12.03.029---
Tracheitis11.01.13.007; 22.07.03.009--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Musculoskeletal disorder15.03.05.025---
Muscle tightness15.05.03.007---
Musculoskeletal stiffness15.03.05.027---
Dental discomfort07.09.06.002---
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