Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Retapamulin
Drug ID BADD_D01928
Description Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Indications and Usage For use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes.
Marketing Status approved
ATC Code D06AX13
DrugBank ID DB01256
KEGG ID D05720
MeSH ID C508887
PubChem ID 6918462
TTD Drug ID D03UQM
NDC Product Code 16110-518
UNII 4MG6O8991R
Synonyms retapamulin | acetic acid, 2-(((3-exo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)thio)-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester | SB 275833 | SB275833 | SB-275833 | Altabax | Altargo
Chemical Information
Molecular Formula C30H47NO4S
CAS Registry Number 224452-66-8
SMILES CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CC5CCC(C4)N5C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Application site irritation08.02.01.003; 12.07.01.003---
Application site pain08.02.01.004; 12.07.01.004---
Application site pruritus08.02.01.005; 12.07.01.005; 23.03.12.004---
Blood creatine phosphokinase increased13.04.01.001--
Body temperature increased13.15.01.001---
Burning sensation08.01.09.029; 17.02.06.001---
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
Diarrhoea07.02.01.001--
Eczema23.03.04.006--
Erythema23.03.06.001---
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001---
Instillation site pain08.02.01.008; 12.07.01.008---
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Pain08.01.08.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Skin disorder23.03.03.007---
Application site paraesthesia08.02.01.026; 12.07.01.026; 17.02.06.012---
Application site burn08.02.01.038; 12.07.01.038; 23.03.11.013---
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