Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirbuterol acetate
Drug ID BADD_D01782
Description Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Indications and Usage For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
Marketing Status approved
ATC Code R03AC08; R03CC07
DrugBank ID DB01291
KEGG ID D00686
MeSH ID C009118
PubChem ID 171674
TTD Drug ID D0SS4P
NDC Product Code Not Available
UNII 1EH73XKR9N
Synonyms pirbuterol | pyrbuterol | CP-24,314-1 | Maxair | pirbuterol dihydrochloride | 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-tert-butylamino ethyl)pyridine, dihydrochloride | pirbuterol sulfate | CP 24315-1 | CP-24315-1 | pirbuterol acetate | pirbuterol acetate salt
Chemical Information
Molecular Formula C14H24N2O5
CAS Registry Number 65652-44-0
SMILES CC(=O)O.CC(C)(C)NCC(C1=NC(=C(C=C1)O)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Palpitations02.11.04.012--
Parosmia17.04.04.002; 22.04.03.007---
Productive cough22.02.03.005--
Pruritus23.03.12.001--
Rash23.03.13.001---
Skin reaction10.01.03.019; 23.03.03.013---
Somnolence17.02.04.006; 19.02.05.003--
Stomatitis07.05.06.005--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tremor17.01.06.002--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Wheezing22.03.01.009--
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Decreased appetite08.01.09.028; 14.03.01.005--
Oropharyngeal pain07.05.05.004; 22.12.03.016--
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