Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penicillin g procaine
Drug ID BADD_D01713
Description Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
Indications and Usage For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
Marketing Status approved; vet_approved
ATC Code Not Available
DrugBank ID DB09320
KEGG ID Not Available
MeSH ID D010402
PubChem ID 22502
TTD Drug ID D0A5LH
NDC Product Code 60793-130; 58775-002; 60793-131
UNII 17R794ESYN
Synonyms Penicillin G Procaine | G Procaine, Penicillin | Procaine, Penicillin G | Benzylpenicillin Procaine | Procaine, Benzylpenicillin | Procaine Penicillin | Penicillin, Procaine | Jenacillin
Chemical Information
Molecular Formula C29H40N4O7S
CAS Registry Number 6130-64-9
SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C.O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Body temperature increased13.15.01.001---
Chills08.01.09.001; 15.05.03.016--
Dermatitis23.03.04.002---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002---
Eosinophilia01.02.04.001--
Fatigue08.01.01.002--
Haemolytic anaemia01.06.03.002---
Hallucination19.10.04.003--
Hypersensitivity10.01.03.003--
Jarisch-Herxheimer reaction10.02.01.002---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Nephropathy20.05.03.001---
Neuropathy peripheral17.09.03.003---
Oedema08.01.07.006; 14.05.06.010---
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Psychotic behaviour19.03.01.003---
Pyrexia08.05.02.003--
Rash23.03.13.001---
Rash maculo-papular23.03.13.004--
Serum sickness10.01.03.004; 12.02.08.004--
Tachycardia02.03.02.007---
Thrombocytopenia01.08.01.002---
Urticaria10.01.06.001; 23.04.02.001--
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