Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegvisomant
Drug ID BADD_D01699
Description Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Indications and Usage Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.
Marketing Status approved
ATC Code H01AX01
DrugBank ID DB00082
KEGG ID D05394
MeSH ID C406545
PubChem ID Not Available
TTD Drug ID D0D6VE
NDC Product Code 0009-7166; 59267-5376; 59267-9301; 59267-9201; 0009-7168; 59267-5201; 59267-9401; 0009-7188; 0009-7200; 64052-001; 0009-7199
UNII N824AOU5XV
Synonyms pegvisomant | B2036-PEG | B-2036 PEG | Somavert
Chemical Information
Molecular Formula Not Available
CAS Registry Number 218620-50-9
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.04.005--
Aspartate aminotransferase increased13.03.04.011--
Back pain15.03.04.005--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Hypertension24.08.02.001--
Infection11.01.08.002---
Influenza11.05.03.001; 22.07.02.001---
Injection site reaction08.02.03.014; 12.07.03.015--
Injury12.01.08.004---
Liver function test abnormal13.03.04.030---
Nausea07.01.07.001--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Sinusitis11.01.13.005; 22.07.03.007--
Transaminases increased13.03.04.036---
Antibody test positive13.06.03.001---
Lipohypertrophy14.08.04.009; 23.07.01.005--
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