Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Paraldehyde
Drug ID BADD_D01672
Description Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypnotic and sedative agent due to its CNS depressant properties. Paraldehyde is used as an ingredient in some cough medicines as an expectorant, but its efficacy for this indication has not been confirmed and its use as an expectorant may possibly be due to a placebo effect.
Indications and Usage Paraldehyde was used historically as a sedative and hypnotic [A19735]. It has been used in the treatment of seizures as an anticonvulsant [A19736].
Marketing Status approved; investigational
ATC Code N05CC05
DrugBank ID DB09117
KEGG ID D00705
MeSH ID D010242
PubChem ID 31264
TTD Drug ID D0P9EA
NDC Product Code Not Available
UNII S6M3YBG8QA
Synonyms Paraldehyde
Chemical Information
Molecular Formula C6H12O3
CAS Registry Number 123-63-7
SMILES CC1OC(OC(O1)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Confusional state17.02.03.005; 19.13.01.001--
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug dependence19.07.06.011---
Feeling abnormal08.01.09.014---
Hepatitis toxic09.01.07.017; 12.03.01.016---
Hyperhidrosis08.01.03.028; 23.02.03.004--
Metabolic acidosis14.01.01.003---
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Rash23.03.13.001---
Skin exfoliation23.03.07.003---
Skin necrosis23.03.03.011---
Subcutaneous abscess11.01.12.007; 23.11.04.008---
Tremor17.01.06.002--
Nerve injury12.01.12.002; 17.02.10.007---
Fat necrosis08.03.03.004---
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