Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status approved
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 13985-602; 17478-713; 24208-410; 60505-0560; 63187-472; 63187-734; 0404-7189; 68071-2265; 68788-8195; 70756-607; 75834-119; 11980-779; 53002-1604; 53002-2604; 50090-5186; 60505-0363; 70518-2037; 71209-099; 70518-0192; 70518-3573; 59116-1820; 68788-8178; 70518-3710; 71205-420; 53069-0440; 53002-1324; 63187-184; 64980-432; 71209-097; 58032-0090; 24208-434; 68071-2254; 68071-2544; 68071-2834; 75834-112; 75834-120; 68071-3448; 68788-7693; 72189-108; 50090-1346; 63187-662; 64980-515; 63187-268; 63629-8716; 68788-8264; 68788-8449; 71209-098; 59390-140
UNII A4P49JAZ9H
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal discomfort15.03.04.001---
Affect lability19.04.01.001---
Haemorrhage24.07.01.002---
Temperature intolerance08.01.09.0220.000167%-
Vasodilation procedure25.03.01.001---
Drug resistance08.06.01.0050.000083%-
Urine output increased13.13.03.002---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Inflammation08.01.05.007; 10.02.01.089---
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.0050.000083%
Ill-defined disorder08.01.03.049---
Sensation of foreign body08.01.09.002---
Artery dissection24.02.01.0030.000083%-
Chondropathy15.07.03.0030.000083%-
Psychotic disorder19.03.01.002--
Urethritis noninfective20.07.02.002---
Vulvovaginal mycotic infection11.03.05.004; 21.14.02.004---
Neuropsychological test abnormal13.07.06.001---
Bone marrow failure01.03.03.005--
Tendon pain15.07.01.0090.000333%-
Psychiatric decompensation19.01.02.0100.000083%-
Acute kidney injury20.01.03.0160.000250%
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.000208%-
Language disorder17.02.08.015; 19.19.01.0060.000083%-
Multiple organ dysfunction syndrome08.01.03.0570.000083%
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.000083%-
Persecutory delusion19.10.01.0070.000083%-
Weight bearing difficulty15.03.05.0340.000167%-
Chemical burns of eye06.11.01.013; 12.03.02.009---
The 10th Page    First    Pre   10 11    Next   Last    Total 11 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene