Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norepinephrine bitartrate
Drug ID BADD_D01584
Description Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Indications and Usage Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Marketing Status approved
ATC Code C01CA03
DrugBank ID DB00368
KEGG ID D05206
MeSH ID D009638
PubChem ID 3047796
TTD Drug ID D07MOX
NDC Product Code 51927-4533; 65392-2301; 51662-1528; 65832-0001; 25021-316; 44567-642; 67457-852; 0409-3375; 66300-001; 44567-640; 0338-0112; 66064-1025; 36000-162; 44567-641; 68083-437; 63323-940; 0781-3755; 38779-2138; 12828-0064; 51991-983; 0338-0108; 65219-140; 72078-002; 0143-9318; 70121-1576; 72572-481; 43066-997; 47335-615
UNII IFY5PE3ZRW
Synonyms Norepinephrine | Levonorepinephrine | Noradrenaline | Levarterenol | Levophed | Levophed Bitartrate | Noradrénaline tartrate renaudin | Norepinephrine Bitartrate | Norepinephrine l-Tartrate (1:1) | Noradrenaline Bitartrate | Norepinephrine d-Tartrate (1:1) | Norepinephrin d-Tartrate (1:1) | Norepinephrine Hydrochloride | Norepinephrine Hydrochloride, (+)-Isomer | Norepinephrine Hydrochloride, (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), (+,-)-Isomer | Norepinephrine l-Tartrate (1:1), Monohydrate | Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer | Norepinephrine l-Tartrate (1:2) | Norepinephrine l-Tartrate, (+)-Isomer | Norepinephrine, (+)-Isomer | Norepinephrine, (+,-)-Isomer | Arterenol | Levonor
Chemical Information
Molecular Formula C12H19NO10
CAS Registry Number 108341-18-0
SMILES C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Bradycardia02.03.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Gangrene11.02.01.003; 23.06.06.001; 24.04.05.003---
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypertension24.08.02.001--
Injection site extravasation08.02.03.002; 12.07.03.002---
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Photophobia06.01.01.004; 17.17.02.006--
Respiratory disorder22.02.07.002---
Vomiting07.01.07.003--
Ischaemia24.04.02.004---
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