Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone hydrochloride
Drug ID BADD_D01547
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status approved; withdrawn
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D00819
MeSH ID C051752
PubChem ID 54911
TTD Drug ID D0X7DE
NDC Product Code 0093-1025; 0093-1026; 63629-7046; 63415-0015; 0093-1024; 0093-7113; 0093-7178
UNII 27X63J94GR
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H33Cl2N5O2
CAS Registry Number 82752-99-6
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abnormal dreams17.15.02.001; 19.02.03.001---
Accommodation disorder06.02.04.001---
Acne23.02.01.001---
Ageusia07.14.03.003; 17.02.07.001---
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anorgasmia19.08.01.001--
Apathy19.04.04.002---
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Ataxia08.01.02.004; 17.02.02.001--
Atrioventricular block02.03.01.002---
Blood lactate dehydrogenase increased13.04.02.002--
Blood prolactin increased13.10.03.002---
Breast enlargement21.05.04.001---
Breast pain21.05.05.003--
Breath odour07.01.06.002---
Bronchitis11.01.09.001; 22.07.01.001--
Bursitis12.04.03.010; 15.04.01.001---
Cardiac failure congestive02.05.01.002---
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