Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Natrecor
Drug ID BADD_D01540
Description Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.
Indications and Usage For the intravenous treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
Marketing Status approved; investigational
ATC Code C01DX19
DrugBank ID DB04899
KEGG ID D05147
MeSH ID D020097
PubChem ID 91976508
TTD Drug ID D05GRY
NDC Product Code 35207-0009
UNII P7WI8UL647
Synonyms Natriuretic Peptide, Brain | Peptide, Brain Natriuretic | BNP-32 | BNP 32 | Brain Natriuretic Peptide-32 | Brain Natriuretic Peptide 32 | Natriuretic Peptide-32, Brain | Peptide-32, Brain Natriuretic | Natriuretic Factor-32 | Natriuretic Factor 32 | BNP Gene Product | Type-B Natriuretic Peptide | Natriuretic Peptide, Type-B | Type B Natriuretic Peptide | Natriuretic Peptide Type-B | Natriuretic Peptide Type B | Nesiritide | Brain Natriuretic Peptide | B-Type Natriuretic Peptide | Natriuretic Peptide, B-Type | Ventricular Natriuretic Peptide, B-type | Ventricular Natriuretic Peptide, B type | Natrecor
Chemical Information
Molecular Formula C143H244N50O42S4
CAS Registry Number 124584-08-3
SMILES CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(CSSCC(C(=O )NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CC SC)CCCCN)CCCNC(=N)N)CC2=CC=CC=C2)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O )C(C(C)C)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C3CCCN3C(=O)C(CO)N)C(=O)NC(CCCCN)C(=O) NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CN=CN4 )C(=O)O)CC(C)C)CO)CO)CO)CO
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001---
Back pain15.03.04.005--
Blood creatinine increased13.13.01.004--
Bradycardia02.03.02.002---
Cardiac failure02.05.01.001--
Coronary artery disease02.02.01.001; 24.04.04.006---
Dermatitis23.03.04.002---
Diabetes mellitus05.06.01.001; 14.06.01.001---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug interaction08.06.03.001---
Dyspnoea02.11.05.003; 22.02.01.004--
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypotension24.06.03.002--
Immune system disorder10.02.01.001---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Pruritus23.03.12.001--
Rash23.03.13.001---
Renal failure20.01.03.005---
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007---
Vomiting07.01.07.003--
Musculoskeletal disorder15.03.05.025---
Angiopathy24.03.02.007---
Renal impairment20.01.03.010---
Infusion site extravasation08.02.05.007; 12.07.05.008--
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