| Drug Name |
Nabumetone |
| Drug ID |
BADD_D01511 |
| Description |
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action.[A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.[L6568] |
| Indications and Usage |
**Indicated** for:[label]
1) Symptomatic relief in rheumatoid arthritis.
2) Symptomatic relief in osteoarthritis. |
| Marketing Status |
approved |
| ATC Code |
M01AX01 |
| DrugBank ID |
DB00461
|
| KEGG ID |
D00425
|
| MeSH ID |
D000077430
|
| PubChem ID |
4409
|
| TTD Drug ID |
D05CKR
|
| NDC Product Code |
49706-0681; 62331-008; 45865-464; 50090-6167; 60760-369; 60760-386; 62135-145; 0591-3671; 80425-0054; 65977-0082; 50228-465; 51655-733; 62135-146; 63629-8508; 69097-966; 72189-184; 76282-257; 15370-170; 69097-965; 71205-978; 71335-1234; 72189-072; 55700-845; 76420-210; 24196-135; 60687-630; 60760-368; 63187-307; 63629-8506; 69367-241; 69367-242; 0591-3670; 79739-7077; 50090-5386; 50228-466; 53002-6960; 61919-668; 68788-7597; 68788-7765; 79739-7076; 80425-0104; 65015-632; 43063-972; 45865-111; 50090-5294; 51655-446; 60760-387; 63187-378; 63629-7699; 63629-8509; 71335-1272; 71335-1391; 45865-997; 55700-840; 61919-609; 71335-1559; 63629-8510; 76282-258; 80425-0053; 63187-484; 71205-030; 71205-530; 71205-977; 72789-040; 79739-7078 |
| UNII |
LW0TIW155Z
|
| Synonyms |
Nabumetone | Nabumeton | 4-(6-Methoxy-2-naphthyl)-2-butanone | Relifex | Relif | Apo-Nabumetone | ApoNabumetone | Mebutan | Listran | Gen-Nabumetone | Arthraxan | BRL 14777 | Rhoxal-nabumetone | Rhoxal nabumetone | Relafen | Nabucox |
