Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Muromonab-cd3
Drug ID BADD_D01506
Description Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Indications and Usage For treatment of organ transplant recipients, prevention of organ rejection
Marketing Status approved; investigational
ATC Code L04AA02
DrugBank ID DB00075
KEGG ID D05092
MeSH ID D016853
PubChem ID Not Available
TTD Drug ID D05GVQ
NDC Product Code Not Available
UNII JGA39ICE2V
Synonyms Muromonab-CD3 | Muromonab CD3 | OKT3 | Monoclonal Antibody OKT3 | Orthoclone OKT3
Chemical Information
Molecular Formula Not Available
CAS Registry Number 140608-64-6
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory tract congestion22.02.07.003---
Musculoskeletal stiffness15.03.05.027---
Vascular occlusion24.04.02.015---
Cytomegalovirus syndrome11.05.01.005---
Cognitive disorder17.03.03.003; 19.21.02.001--
Staphylococcal infection11.02.05.002---
Vasodilation procedure25.03.01.001---
Adenovirus infection11.05.09.003---
Bacterial infection11.02.01.005---
Central nervous system infection11.01.03.004; 17.06.09.001---
Eyelid disorder06.08.03.010; 23.03.03.028---
Legionella infection11.02.16.001---
Decreased appetite08.01.09.028; 14.03.01.005--
Serratia infection11.02.25.001---
Cytomegalovirus test13.08.03.004---
Neoplasm recurrence16.16.02.004---
Obstructive airways disorder22.03.01.011---
Cranial nerve paralysis17.04.01.002---
Psychotic disorder19.03.01.002--
Urinary sediment abnormal13.13.02.007---
Renal impairment20.01.03.010---
Brain stem thrombosis17.08.01.034; 24.01.04.011---
Breath sounds abnormal13.15.01.008---
Treatment failure08.06.01.017---
Renal cell carcinoma16.08.02.002; 20.01.04.003---
Hepatitis B virus test13.08.03.009---
Hepatitis C virus test13.08.03.011---
Pneumocystis jirovecii infection11.03.07.004---
Delayed graft function12.02.09.015---
Herpes simplex test positive13.08.03.038---
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