Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Muromonab-cd3
Drug ID BADD_D01506
Description Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Indications and Usage For treatment of organ transplant recipients, prevention of organ rejection
Marketing Status approved; investigational
ATC Code L04AA02
DrugBank ID DB00075
KEGG ID D05092
MeSH ID D016853
PubChem ID Not Available
TTD Drug ID D05GVQ
NDC Product Code Not Available
UNII JGA39ICE2V
Synonyms Muromonab-CD3 | Muromonab CD3 | OKT3 | Monoclonal Antibody OKT3 | Orthoclone OKT3
Chemical Information
Molecular Formula Not Available
CAS Registry Number 140608-64-6
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.034--
Adenocarcinoma16.16.01.004---
Adrenal insufficiency05.01.02.001; 14.11.01.004--
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angina pectoris02.02.02.002; 24.04.04.002--
Anuria20.01.03.002---
Aphasia17.02.03.001; 19.21.01.001--
Aplastic anaemia01.03.03.002---
Apnoea22.02.01.001--
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Aspartate aminotransferase increased13.03.04.011--
Asterixis09.01.03.004; 17.01.06.001---
Asthenia08.01.01.001---
Azotaemia20.01.01.001---
Blindness06.02.10.003; 17.17.01.003---
Blood pressure fluctuation24.06.01.002---
Bradycardia02.03.02.002---
Brain herniation12.01.10.001; 17.07.02.009---
Breast cancer16.10.01.001; 21.05.01.003---
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Central nervous system neoplasm16.30.01.001; 17.20.01.001---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
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