| Pharmaceutical Information |
| Drug Name |
Mupirocin calcium |
| Drug ID |
BADD_D01505 |
| Description |
Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism _Pseudomonas fluorescens_, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative bacteria _in vitro_.[L10580] It primarily works by inhibiting bacterial protein synthesis. Due to its unique mode of action of inhibiting the activity of bacterial isoleucyl-tRNA synthetase, mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents, giving it a therapeutic advantage.[L10580] It is available in topical formulations only due to extensive systemic metabolism[A178531] and is used in the treatment of impetigo caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_ and traumatic skin lesions due to secondary skin infections caused by _S. aureus_ and _S. pyogenes_. There is also some clinical evidence that suggests the potential role of mupirocin in eradicating nasal carriage of Staphylococci when administered intranasally.[A178531,A178591] Mupirocin is commonly marketed under the brand name Bactroban. |
| Indications and Usage |
Indicated for the treatment of impetigo and secondary skin infections, leading to traumatic skin lesions, due to _Staphylococcus aureus_ and _Streptococcus pyogenes_.[L10580] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
D06AX09; R01AX06 |
| DrugBank ID |
DB00410
|
| KEGG ID |
D02195
|
| MeSH ID |
D016712
|
| PubChem ID |
5282317
|
| TTD Drug ID |
D03JSJ
|
| NDC Product Code |
51846-1046; 65897-1007; 68254-2505; 70518-3774; 65897-2007; 68254-0011; 16714-055; 51672-1370 |
| UNII |
RG38I2P540
|
| Synonyms |
Mupirocin | Pseudomonic Acid A | Mupirocin Calcium | Mupirocin, Sodium Salt | Mupirocin, Lithium Salt | BRL-4910A | BRL 4910A | BRL4910A | Mupirocin, 14C-Labeled | 14C-Labeled Mupirocin | Mupirocin, 14C Labeled | Mupirocin, Calcium Salt (2:1) | Mupirocin, Calcium Salt (2:1), Dihydrate | Pseudomonic Acid | Bactroban |
|
| Chemical Information |
| Molecular Formula |
C52H90CaO20 |
| CAS Registry Number |
115074-43-6 |
| SMILES |
CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)C(C)O.CC(C1C(O1)CC2COC(C
(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)C(C)O.O.O.[Ca+2] |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
|
|
|
