Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mepivacaine
Drug ID BADD_D01387
Description A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Indications and Usage For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Marketing Status approved; vet_approved
ATC Code N01BB03
DrugBank ID DB00961
KEGG ID D08181
MeSH ID D008619
PubChem ID 4062
TTD Drug ID D0WO8W
NDC Product Code 52932-0745
UNII B6E06QE59J
Synonyms Mepivacaine | Mepivacaina Braun | Isogaine | Meaverin | Mecain | Mepihexal | Mepivacain-Injektopas | Mepivacain Injektopas | Mepivacaine Hydrochloride | Mepivacaine Monohydrochloride | Mepivastesin | Polocaine | Scandinibsa | Scandonest | Scandicain | Scandicaine | Carbocaine | Carbocaïne | Isocaine
Chemical Information
Molecular Formula C15H22N2O
CAS Registry Number 96-88-8
SMILES CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Aggression19.05.01.0010.000268%-
Agitation17.02.05.012; 19.06.02.0010.000268%
Amnesia17.03.02.001; 19.20.01.0010.000179%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000268%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000357%-
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.000268%-
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Asthenia08.01.01.001---
Atrioventricular block02.03.01.002---
Back pain15.03.04.005--
Body temperature increased13.15.01.001---
Bradycardia02.03.02.0020.000357%-
Brain hypoxia17.08.02.009; 22.02.02.010; 24.04.06.022---
Cardiac arrest02.03.04.0010.000357%
Cardiac output decreased13.14.02.001---
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000179%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.0030.000179%-
Chills08.01.09.001; 15.05.03.016--
Circulatory collapse24.06.02.0010.000179%-
Confusional state17.02.03.005; 19.13.01.0010.000179%
Discomfort08.01.08.0030.000179%-
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.001322%
Drug hypersensitivity10.01.01.0010.001000%-
Drug ineffective08.06.01.0060.021828%-
Dysarthria17.02.08.001; 19.19.03.0010.000268%
Dysgeusia07.14.03.001; 17.02.07.0030.000393%
Dysphagia07.01.06.0030.000268%
The 1th Page    1 2 3 4    Next   Last    Total 4 Pages