Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mafenide acetate
Drug ID BADD_D01338
Description Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
Indications and Usage Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.[label]
Marketing Status approved; vet_approved
ATC Code D06BA03
DrugBank ID DB06795
KEGG ID D01166
MeSH ID D008272
PubChem ID 25590
TTD Drug ID D0K1QD
NDC Product Code 50742-310; 42973-157; 49884-902; 65015-889; 16571-723; 65392-2801
UNII RQ6LP6Z0WY
Synonyms Mafenide | Maphenid | Mafenide Acetate | Sulfamylon | Marfanil | Napaltan | 4-Homosulfanilamide | 4 Homosulfanilamide | Sulfabenzamine | Bensulfamide | Mafylon
Chemical Information
Molecular Formula C9H14N2O4S
CAS Registry Number 13009-99-9
SMILES CC(=O)O.C1=CC(=CC=C1CN)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Application site pain08.02.01.004; 12.07.01.004---
Blister12.01.06.002; 23.03.01.001---
Blood chloride increased13.11.01.005---
Blood gases abnormal13.02.01.007---
Death08.04.01.001--
Diarrhoea07.02.01.001--
Disseminated intravascular coagulation01.01.02.002; 24.01.01.010--
Eosinophilia01.02.04.001--
Erythema23.03.06.001---
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Haemolytic anaemia01.06.03.002---
Hyperventilation19.01.02.004; 22.02.01.006---
Porphyria acute03.08.01.002; 09.01.10.001; 14.14.01.002; 17.19.01.001; 19.07.03.003---
Pruritus23.03.12.001--
Swelling08.01.03.015---
Tachypnoea22.02.01.014---
Urticaria10.01.06.001; 23.04.02.001--
Skin burning sensation17.02.06.009; 23.03.03.021---
Skin haemorrhage23.06.07.001; 24.07.01.103---
Skin abrasion12.01.06.010; 23.03.11.018---
Bone marrow failure01.03.03.005--
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