Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loracarbef
Drug ID BADD_D01316
Description Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Indications and Usage Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.
Marketing Status approved; investigational; withdrawn
ATC Code J01DC08
DrugBank ID DB00447
KEGG ID D00916; D08143
MeSH ID C054920
PubChem ID 5284585
TTD Drug ID D0E9WL
NDC Product Code Not Available
UNII 3X11EVM5SU
Synonyms loracarbef | KT 3777 | KT-3777 | Lorabid | Lorafem | Lorax | LY 163892 | LY163892 | LY-163892 | Carbac | loracarbef monohydrate
Chemical Information
Molecular Formula C16H16ClN3O4
CAS Registry Number 76470-66-1
SMILES C1CC(=C(N2C1C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombocytopenia01.08.01.002---
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Urticaria10.01.06.001; 23.04.02.001--
Vaginal infection11.01.10.002; 21.14.02.002--
Vasodilatation23.06.05.006; 24.03.02.003---
Vomiting07.01.07.003--
Vulvovaginal candidiasis11.03.03.005; 21.14.02.003---
Haemorrhage24.07.01.002---
Blood alkaline phosphatase increased13.04.02.004--
Decreased appetite08.01.09.028; 14.03.01.005--
Renal impairment20.01.03.010---
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