Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Isosorbide dinitrate
Drug ID BADD_D01210
Description A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Indications and Usage For the prevention of angina pectoris due to coronary artery disease.
Marketing Status approved; investigational
ATC Code C01DA08; C05AE02
DrugBank ID DB00883
KEGG ID D00516
MeSH ID D007548
PubChem ID 6883
TTD Drug ID D0I1SK
NDC Product Code 0781-1635; 16714-010; 51407-148; 70771-1502; 0615-8465; 72888-084; 16714-007; 16714-008; 0143-1772; 42291-350; 55154-7991; 63629-9593; 68001-374; 68084-083; 0615-8157; 0781-1556; 43353-141; 49884-020; 49884-022; 68084-082; 70518-3444; 70518-3637; 0615-8193; 63739-367; 68001-373; 68682-193; 72888-085; 0143-1769; 0143-1771; 70518-2306; 70710-1150; 70771-1504; 70771-1505; 72888-083; 0904-6620; 0187-0192; 49884-021; 49884-556; 63739-569; 68001-375; 68682-192; 70518-0063; 70710-1148; 0615-8294; 72888-081; 46438-0634; 16714-009; 0187-0152; 49884-009; 0615-8464; 0781-1695; 0904-6619; 50268-447; 70710-1149; 70710-1151; 70771-1501; 0615-8463; 50268-448; 50268-449; 51407-147; 70518-1435; 70518-2817; 70771-1503; 72888-082; 46438-0001; 51407-149; 68001-562; 70710-1152; 43353-139; 55154-7990
UNII IA7306519N
Synonyms Isosorbide Dinitrate | Dinitrate, Isosorbide | Dilatrate | Iso-Bid | Iso Bid | IsoBid | Isodinit | Isoket | Sorbonit | Isomak R | Isordil | Isotrate | Nitrosorbide | Sorbitrate | Cardonit 40 | Isoket Retard-120 | Isoket Retard 120 | Isoket Retard120
Chemical Information
Molecular Formula C6H8N2O8
CAS Registry Number 87-33-2
SMILES C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000411%-
Angina pectoris02.02.02.002; 24.04.04.0020.000411%
Angina unstable02.02.02.004; 24.04.04.004---
Asthenia08.01.01.0010.000411%-
Blood pressure abnormal13.14.03.001---
Bradycardia02.03.02.002---
Cardiac failure02.05.01.0010.002669%
Dermatitis23.03.04.002---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000903%
Drug hypersensitivity10.01.01.0010.002793%-
Drug ineffective08.06.01.0060.001314%-
Drug interaction08.06.03.001---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.0010.001396%
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.0030.001396%
Hypertension24.08.02.001--
Hypotension24.06.03.0020.001930%
Loss of consciousness17.02.04.004---
Malaise08.01.01.0030.000411%
Methaemoglobinaemia01.05.01.002--
Myocardial infarction02.02.02.007; 24.04.04.0090.001109%
Myocardial ischaemia02.02.02.008; 24.04.04.0100.003573%-
Nausea07.01.07.0010.001109%
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oral discomfort07.05.05.0010.001396%-
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Pruritus23.03.12.001--
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