Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Irinotecan
Drug ID BADD_D01195
Description Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Indications and Usage For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
Marketing Status approved; investigational
ATC Code L01CE02
DrugBank ID DB00762
KEGG ID D08086
MeSH ID D000077146
PubChem ID 60838
TTD Drug ID D07HOB
NDC Product Code 68554-0054
UNII 7673326042
Synonyms Irinotecan | Irrinotecan | Camptothecin-11 | Camptothecin 11 | SN 38 11 | SN-38-11 | SN3811 | SN 38 | SN-38 | NK012 Compound | CPT-11 | CPT11 | CPT 11 | Camptosar | 7-Ethyl-10-hydroxycamptothecin | 7 Ethyl 10 hydroxycamptothecin | Irinotecan Hydrochloride
Chemical Information
Molecular Formula C33H38N4O6
CAS Registry Number 97682-44-5
SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC 7
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal failure20.01.03.005---
Respiratory failure14.01.04.003; 22.02.06.0020.000336%
Rhinitis11.01.13.004; 22.07.03.006--
Salivary hypersecretion07.06.01.009---
Skin lesion23.03.03.0100.000112%-
Small intestinal obstruction07.13.06.0010.000112%
Sneezing22.12.03.0240.000112%
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.0270.000504%-
Stomatitis07.05.06.0050.000448%
Strabismus06.05.02.004; 17.17.01.0090.000168%-
Swelling08.01.03.015---
Swollen tongue07.14.02.003; 10.01.05.015; 23.04.01.0140.000224%-
Tachycardia02.03.02.0070.000168%-
Throat irritation07.05.05.037; 22.12.03.0290.000246%-
Thrombocytopenia01.08.01.0020.000336%-
Tongue disorder07.14.01.0020.000280%-
Transient ischaemic attack17.08.04.001; 24.04.06.0050.000112%
Ulcer08.03.06.001---
Urinary retention20.02.02.0110.000246%
Urticaria10.01.06.001; 23.04.02.0010.000280%
Vasodilatation23.06.05.006; 24.03.02.003---
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.0030.002653%
Weight decreased13.15.01.005--
Wheezing22.03.01.0090.000112%
General physical health deterioration08.01.03.0180.000336%-
Deep vein thrombosis24.01.02.003---
Malignant neoplasm progression16.16.01.0050.001175%-
Gastrointestinal hypermotility07.02.04.005---
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ADReCS-Target
Drug Name ADR Term Target
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