Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hetastarch
Drug ID BADD_D01066
Description Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
Indications and Usage An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
Marketing Status approved
ATC Code Not Available
DrugBank ID DB09106
KEGG ID D03335
MeSH ID D006895
PubChem ID 24846132
TTD Drug ID Not Available
NDC Product Code 0409-1555; 18124-009; 0409-7248
UNII 875Y4127EA
Synonyms Hydroxyethyl Starch Derivatives | Derivatives, Hydroxyethyl Starch | Starch Derivatives, Hydroxyethyl | Hydroxyethylated Starches | Starches, Hydroxyethylated | Starches, 2-Hydroxyethyl | 2-Hydroxyethyl Starches | Starches, 2 Hydroxyethyl | Hemohes | Elohes | Hespan | Hetastarch | Pentafraction | Pentaspan | Pentastarch | Plasmasteril | HAES-steril | Hydroxyethyl Starch 130-0.4 | Hydroxyethyl Starch 130 0.4 | Hydroxyethyl Starch (130 KD-0.4 Substitution)
Chemical Information
Molecular Formula C29H52O21
CAS Registry Number 9004-62-0
SMILES CC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)OC)O)O)OC4C(C(C(C(O4)CO)OC)O)OC CO)O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Anaemia01.03.02.001--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Chills08.01.09.001; 15.05.03.016--
Coagulopathy01.01.02.001---
Cough22.02.03.001--
Death08.04.01.001--
Dermatitis23.03.04.002---
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema multiforme10.01.03.015; 23.03.01.003--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Factor VIII deficiency01.01.01.005; 03.15.01.002---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Haematocrit decreased13.01.05.001---
Haemoglobin13.01.05.018---
Haemorrhage intracranial17.08.01.008; 24.07.04.003--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Immune system disorder10.02.01.001---
Influenza like illness08.01.03.010--
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
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