Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Granisetron hydrochloride
Drug ID BADD_D01041
Description A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Indications and Usage For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
Marketing Status approved; investigational
ATC Code A04AA02
DrugBank ID DB00889
KEGG ID D00677
MeSH ID D017829
PubChem ID 6918003
TTD Drug ID D04NLG
NDC Product Code 53104-7732; 0143-9745; 63323-318; 69452-350; 42043-390; 0143-9744; 67457-861; 17478-546; 55150-176; 51916-323; 67457-863; 51991-735; 14778-0303; 63323-319; 14096-102; 67457-864; 64567-0009; 58175-0360; 63850-0005; 65129-1135; 55150-175
UNII 318F6L70J8
Synonyms Granisetron | 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide | Kytril | BRL-43694A | BRL 43694A | BRL43694A | BRL-43694 | BRL 43694 | BRL43694 | Granisetron Hydrochloride | Hydrochloride, Granisetron | Granisetron Monohydrochloride | Monohydrochloride, Granisetron
Chemical Information
Molecular Formula C18H25ClN4O
CAS Registry Number 107007-99-8
SMILES CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.04.005--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anxiety19.06.02.002--
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002---
Constipation07.02.02.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram abnormal13.14.05.001---
Electrocardiogram QT prolonged13.14.05.004--
Headache17.14.01.001--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Sinus bradycardia02.03.03.009--
Tachycardia02.03.02.007---
Urticaria10.01.06.001; 23.04.02.001--
Ventricular extrasystoles02.03.04.007---
Reperfusion arrhythmia02.03.02.010---
Central nervous system stimulation25.04.01.001---
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